1
UI - ML893-0005
AU - Kang BC
AU - Johnson J
AU - Veresthorner C
TI - ATOPIC PROFILE OF INNER-CITY ASTHMA WITH A COMPARATIVE ANALYSIS ON
THE COCKROACH-SENSITIVE AND RAGWEED-SENSITIVE SUBGROUPS
SO - Journal of Allergy & Clinical Immunology. 92(6):802-811, 1993 Dec.
IS - 0091-6749
MH - Inner-city asthma
MH - Aeroallergens
MH - Cockroach allergy
MH - Ige antibody
MH - Indoor allergen
MH - Bronchial-asthma. House dust. Allergic-asthma. Serum ige. Mite.
MH - Children. Antigens. Cat. Prevalence. Population
AB - Background: Inner-city asthma is well known for its high risk of
mortality. To better understand urban asthma, we examined clinical
characteristics and aeroallergen sensitivities of 592 of 680
consecutive urban Chicago residents with asthma.
Methods: A total of 227 male and 453 female subjects who met the
criteria for the study were registered. A comprehensive clinical
evaluation was followed by allergy skin testing (prick and
intradermal testing) with 10 groupings (5 indoor and 5 outdoor) of
common aeroallergens. Serum total IgE and selective antigen-specific
IgE levels, including cockroach-specific IgE, were routinely
measured. A total of 592 (196 male and 396 female) subjects with an
average age of 35 years were skin tested The average duration of
asthma was 12 6 years, and 31% of the population was receiving
corticosteroids.
Results: Aeroallergen sensitivity was noted in 85%, and 94 subjects
(15%) were nonallergic. House dust sensitivity (76%) was most
prevalent, distantly followed by sensitivity to cockroach (48%),
ragweed (45%), other weeds (42%), cat (40%), and dust mite (24%).
The average number of aeroallergen sensitivities detected was 4 of
10 groupings of both and outdoor allergens. Twenty percent of
subjects were allergic to only indoor allergens, whereas 4% were
allergic to outdoor allergens only. Serum IgE was 245 +/- 17.3 IU/ml
(geometric mean + SEM), and 74% of 444 serum samples assayed showed
IgE antibody levels greater than or equal to 100 IU/ml. A
cockroach-sensitive subgroup (283 subjects) had longer duration of
asthma (p < 0. 0001) and fewer additional aeroallergen sensitivities
(p < 0.0001) than the ragweed-sensitive subgroup (264 subjects).
Conclusion: The results indicate that a great majority (85%) of
inner-city Chicago residents with asthma have atopic asthma, as
demonstrated by highly elevated IgE levels and multiple aeroallergen
sensitivities. Sensitivity to indoor allergens is more prevalent
than sensitivity to outdoor allergens. The subjects with
cockroach-sensitive asthma appear to be a distinctive subgroup
characterized by chronicity and elevated serum IgE antibody levels
with fewer aeroallergen skin test sensitivities. [References: 46]
LG - English
PT - Article
SB - Current Contents/Life Sciences
Current Contents/Clinical Medicine
IN - Reprint available from:
Kang BC
UNIV KENTUCKY
KENTUCKY CLIN
DEPT MED
K528
LEXINGTON, KY 40536
USA
MT SINAI HOSP
RUSH MED SCH
CHICAGO, IL
USA
2
UI - ML341-0009
AU - Michils A
AU - Casimir G
AU - Yernault JC
AU - Gossart B
AU - Duchateau J
TI - A DIFFERENT PROFILE OF EPITOPIC DOMINANCE IN THE IMMUNOGLOBULIN-G
RESPONSE TO BOVINE BETALACTOGLOBULIN IN LUNG CANCER
SO - Cancer. 72(12):3607-3613, 1993 Dec 15.
IS - 0008-543X
MH - Bovine betalactoglobulin
MH - Pepsin hydrolysis
MH - Immunoglobulin-g antibody
MH - Epitopic dominance
MH - Lung cancer
MH - Cathepsin-b. Proteinase. Immune. Invasion
AB - Background. The authors previously documented a quantitative defect
in the immunoglobulin G (IgG) response toward bovine
betalactoglobulin (BLG), the major cow's milk antigen, and antigen
pi of the house dust mite, Dermatophagoides pteronyssinus (Der p1),
in patients with lung cancer. In the Der pi model, the authors
documented at the IgG level an epitope specificity that differed
between patients with lung cancer (preferential specificity for
cryptic epitopes) and healthy control subjects and patients with
mite allergy. The current study investigated whether this varying
specificity might be extended to the IgG response toward BLG.
Methods. The authors compared the IgG binding to native BLG (nBLG)
and its products of pepsin hydrolysis (dBLG) in a solid-phase
enzyme-linked immunosorbent assay (ELISA) using
peroxidase-conjugated protein A in 120 patients with lung cancer, 52
patients with chronic obstructive pulmonary disease (COPD) who were
closely matched for age, sex, and smoking habits with the patients
with cancer, and 120 healthy control subjects (blood donors).
Results. Expressing the ratio between optical densities observed for
dBLG and nBLG, respectively, the authors documented two groups:
patient with lung cancer with higher levels of binding on dBLG (mean
ratio +/- SD, 1.66 +/- 0.26) and healthy control subjects and
patients with COPD with similar levels of retention for dBLG and
nBLG (mean ratios +/- SD, 1.00 +/- 0.10 and 1.01 +/- 0.07,
respectively). Influence of population characteristics could be
excluded. The histologic type of cancer and its extent had no
influence on the defined ratio.
Conclusion. These results suggest a preferential recognition of
epitopes unmasked by pepsin hydrolysis (cryptic epitopes?) by lung
cancer IgG, contrasting with the preferential specificity of IgG
from healthy control subjects and patients with COPD for structural
epitopes unaffected by the proteolysis. These findings are similar
to those observed previously with Der pi and indicate a varying, and
possibly specific, profile of epitopic dominance in the IgG response
to antigens naturally presented at the mucosal level in patients
with lung carcinoma, a model of mucosal cancer. [References: 29]
LG - English
PT - Article
SB - Current Contents/Life Sciences
Current Contents/Clinical Medicine
IN - Reprint available from:
Michils A
UNIV BRUSSELS
ERASME HOSP
DEPT CHEST
ROUTE LENNIK 808
B-1070 BRUSSELS
BELGIUM
FREE UNIV BRUSSELS
ST PIERRE HOSP
DEPT IMMUNOL
B-1050 BRUSSELS
BELGIUM
3
UI - ML242-0009
AU - Vanhagehamsten M
AU - Harfast B
AU - Johansson SGO
TI - DUST MITE ALLERGY - AN IMPORTANT CAUSE OF RESPIRATORY DISEASE IN
FARMERS
SO - American Journal of Industrial Medicine. 25(1):47-48, 1994 Jan.
IS - 0271-3586
MH - Lepidoglyphus destructor
MH - Storage mites
MH - Occupational asthma
MH - Organic dusts
MH - Storage mites. Lepidoglyphus-destructor. Farming population
AB - In 2,578 Swedish farmers, 6.2% were found to have an allergy to
storage mites. The storage mite Lepidoglyphus destructor has been
identified by both RAST and bronchial challenges as a significant
cause of occupational asthma in rural environments.
Immunohistochemical studies of L. destructor disclosed that at least
one L. destructor allergen is associated with digestion. (C) 1994
Wiley-Liss, Inc. [References: 12]
LG - English
PT - Note
SB - Current Contents/Clinical Medicine
IN - Reprint available from:
Vanhagehamsten M
KAROLINSKA HOSP
DEPT CLIN IMMUNOL
BOX 60500
S-10401 STOCKHOLM
SWEDEN
4
UI - MJ029-0005
AU - Massey DG
AU - Fourniermassey G
AU - James RH
TI - MINIMIZING ACARIANS AND HOUSE DUST IN THE TROPICS
SO - Annals of Allergy. 71(5):439-444, 1993 Nov.
IS - 0003-4738
MH - Acaricide. Mites
AB - Dust collection and mite isolation by Furumizo's method occurred in
33 homes on days 0 and 14. The first application of Paragerm AK (23
homes) or placebo aerosol (ten homes) was done after vacuuming on
day 14. The second (final) spraying occurred on day 28, immediately
after vacuuming. Vacuum collections without spraying were done on
days 56 and 84 in this randomized double-blind trial.
With Paragerm, dust volume fell to 80.3% of initial levels by day
28, remained low at 8 7.9% (P < .05) on day 56, and then rose to
115.9% by day 84. In control homes, comparative dust values were
89.0%, 103.7%, and 109.9%. With Paragerm, mite concentration
decreased to 70.8% by day 28 (P < .01), to 65% at day 56 (P < .025),
and continued to fall to 47.7% by day 84 (P <. 05). With control
aerosol, mite numbers rose compared with initial values: 119.1% at
day 28, 22 7.2% at day 56, and 125.1% at day 84.
No adverse effects were observed in Paragerm homes besides odor (70%
complained). The two asthmatic occupants improved symptomatically
and took less medication following the Paragerm.
In conclusion, Paragerm, used over 40 years in Europe, is an
effective, nontoxic acaricide in Hawaii, acting promptly and for at
least 2 months. It was also associated with diminished dust volume,
important in nondust allergy. [References: 24]
LG - English
PT - Article
SB - Current Contents/Clinical Medicine
IN - Reprint available from:
Massey DG
KUAKINI MED CTR
347 N KUAKINI ST
HONOLULU, HI 96817
USA
JOHN A BURNS SCH MED
HONOLULU, HI
USA
5
UI - MJ029-0010
AU - Piazza I
AU - Bizzaro N
TI - HUMORAL RESPONSE TO SUBCUTANEOUS, ORAL, AND NASAL IMMUNOTHERAPY FOR
ALLERGIC RHINITIS DUE TO DERMATOPHAGOIDES-PTERONYSSINUS
SO - Annals of Allergy. 71(5):461-469, 1993 Nov.
IS - 0003-4738
MH - Igg subclass antibodies. House dust mite. Hay-fever.
MH - Hyposensitization. Extract. Desensitization. Interleukin-4.
MH - Children. Efficacy. Asthma
AB - We investigated variations in total IgE, and specific IgE, IgG, and
IgG4 for Dermatophagoides pteronyssinus in 5 7 Patients with
perennial rhinitis due to house dust mite allergy in an open
controlled study: 43 subjects received immunotherapy (17
subcutaneous, 14 sublingual, and 12 local immunotherapy) and 14 were
controls. The results were compared with the clinical course to
determine possible associations between serum and clinical changes.
Subcutaneous, but not sublingual and nasal, immunotherapy induced a
significant clinical benefit (P < .001). Specific antibody behavior
in patients receiving subcutaneous immunotherapy was similar to
literature reports. Specific IgE levels fell starting from the 6th
month of therapy, and specific IgG and IgG4 levels rose
significantly, but there was no correlation with the clinical
course. The other two forms of immunotherapy did not induce
significant specific antibody modifications. We conclude that the
specific IgG4 rise induced by subcutaneous immunotherapy was the
most important variation observed. This change, however, was not
correlated with the clinical outcome. [References: 37]
LG - English
PT - Article
SB - Current Contents/Clinical Medicine
IN - Reprint available from:
Piazza I
VIA MONTE PIANA 9
I-30027 SAN DONA DI PIAVE
ITALY
HOSP SAN DONA PIAVE
DEPT INTERNAL MED
VENICE
ITALY
HOSP SAN DONA PIAVE
CLIN PATHOL LAB
VENICE
ITALY
6
UI - ME356-0003
AU - Peat JK
AU - Tovey E
AU - Mellis CM
AU - Leeder SR
AU - Woolcock AJ
TI - IMPORTANCE OF HOUSE DUST MITE AND ALTERNARIA ALLERGENS IN CHILDHOOD
ASTHMA - AN EPIDEMIOLOGICAL STUDY IN 2 CLIMATIC REGIONS OF AUSTRALIA
SO - Clinical & Experimental Allergy. 23(10):812-820, 1993 Oct.
IS - 0954-7894
MH - Dose-response slope. Respiratory symptoms. Bronchial
MH - hyperresponsiveness. Grass-pollen. Serum ige. P-i. Children.
MH - Population. Exposure. Responsiveness
AB - The relation of house dust mite allergen levels to asthma and
allergy was examined in two population samples of children aged 8-11
years in northern New South Wales. We studied 805 children in
Lismore (a hot, humid, coastal region) and 770 in Moree/Narrabri (a
hot, dry inland region). Respiratory symptoms were measured by
questionnaire, bronchial hyperresponsiveness (BHR) by histamine
inhalation test, and allergy by skin-prick tests. Current asthma was
defined as the presence of both wheeze in last 12 months and BHR.
Der p I levels were measured in dust from the bed and floors in the
homes of 57 randomly selected children in the coastal region and of
74 inland children. Der p I levels were significantly higher by the
coast (83.0 vs 11.2 mug/g, P<0.001). House dust mite sensitivity was
of similar prevalence in both regions (28.6 vs 26.4%, n.s.) but
Alternaria sensitivity was higher inland (4.0 vs 15.2% P<0.001).
Bronchial responsiveness was more severe in coastal children
sensitized to house dust mites and in inland children who were
sensitized to Alternaria. The adjusted odds ratios for current
asthma in children sensitized to house dust mites were 21.3 (95% CI
10.5, 43.2) by the coast and 2.7 (95% CI 1.3, 5.4) inland, and in
children sensitized to Alternaria were 3.4 (95% CI 1.3, 9.1) in the
coastal region and 5.6 (95% CI 3.1, 10.1 inland. These studies
suggest that high house dust mite allergen levels in a humid,
subtropical region act to significantly increase bronchial
responsiveness in sensitized children, and that Alternaria allergens
have a similar but less potent action in a dry, rural region.
[References: 36]
LG - English
PT - Article
SB - Current Contents/Life Sciences
Current Contents/Clinical Medicine
IN - Reprint available from:
Woolcock AJ
ROYAL PRINCE ALFRED HOSP
INST RESP MED
ALLEN & HANBURYS EPIDEMIOL UNIT
SYDNEY
NSW 2050
AUSTRALIA
ROYAL PRINCE ALFRED HOSP
INST RESP MED
ALLEN & HANBURYS EPIDEMIOL UNIT
SYDNEY
NSW 2050
AUSTRALIA
UNIV SYDNEY
DEPT MED
SYDNEY
NSW 2006
AUSTRALIA
WESTMEAD HOSP
DEPT COMMUNITY MED
SYDNEY
AUSTRALIA
7
UI - LZ170-0005
AU - Steurich F
TI - ALLERGY TO MIDGES (CHIRONOMIDS) AND BLOODWORMS [German]
SO - Allergologie. 16(9):374-378, 1993 Sep.
IS - 0344-5062
MH - Allergy to fish food
MH - Chironomidae
MH - Insect dust as inhalant allergen
AB - Chironomidae species exist worldwide. They occur close to water
bodies as non-biting midges in ''dancing swarms''. Dust particles of
these insects are part of the airborne dust (<10 mum in diameter)
and represent a widespread inhalant allergen. Blood-worm larvae are
red coloured because of their high haemoglobin content. They are
used as bait and are sold freeze-dried as fish food for aquariums.
Their common and very potent antigen are low molecular fractions of
haemoglobin (erythrocruorine). Two patients are described with an
extreme hypersensitivity to aquarium fish food based on chironomids.
In the anamnesis of allergic persons it is absolutely necessary to
ask explicitly for aquariums, fishing hobbies, fish food and bait.
LG - German
PT - Article
SB - Current Contents/Clinical Medicine
IN - Reprint available from:
Steurich F
FRIEDRICH EBERT STR 40
D-66763 DILLINGEN
GERMANY